Transparent reporting of multivariable prediction models developed or validated using clustered data (TRIPOD-Cluster): explanation and elaboration

TPA Debray, GS Collins, RD Riley, KIE Snell, Calster B Van, JB Reitsma, KGM Moons

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Abstract

The TRIPOD-Cluster (transparent reporting of multivariable prediction models developed or validated using clustered data) statement comprises a 19 item checklist, which aims to improve the reporting of studies developing or validating a prediction model in clustered data, such as individual participant data meta-analyses (clustering by study) and electronic health records (clustering by practice or hospital). This explanation and elaboration document describes the rationale; clarifies the meaning of each item; and discusses why transparent reporting is important, with a view to assessing risk of bias and clinical usefulness of the prediction model. Each checklist item of the TRIPOD-Cluster statement is explained in detail and accompanied by published examples of good reporting. The document also serves as a reference of factors to consider when designing, conducting, and analysing prediction model development or validation studies in clustered data. To aid the editorial process and help peer reviewers and, ultimately, readers and systematic reviewers of prediction model studies, authors are recommended to include a completed checklist in their submission.
Original languageEnglish
Article numbere071058
JournalBMJ
Issue number380
DOIs
Publication statusPublished - 7 Feb 2023

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