TY - CHAP
T1 - Translational biomarkers in the era of precision medicine
AU - Bravo-Merodio, Laura
AU - Acharjee, Animesh
AU - Russ, Dominic
AU - Bisht, Vartika
AU - Williams, John
AU - Tsaprouni, Loukia
AU - Gkoutos, Georgios
PY - 2020/10/3
Y1 - 2020/10/3
N2 - In this chapter we discuss the past, present and future of clinical biomarker development. We explore the advent of new technologies, paving the way in which health, medicine and disease is understood. This review includes the identification of physicochemical assays, current regulations, the development and reproducibility of clinical trials, as well as, the revolution of omics technologies and state-of-the-art integration and analysis approaches.
AB - In this chapter we discuss the past, present and future of clinical biomarker development. We explore the advent of new technologies, paving the way in which health, medicine and disease is understood. This review includes the identification of physicochemical assays, current regulations, the development and reproducibility of clinical trials, as well as, the revolution of omics technologies and state-of-the-art integration and analysis approaches.
KW - translational biomarkers
KW - omics
KW - big data
KW - artificial intelligence
KW - clinical trials
UR - http://dx.doi.org/10.1016/bs.acc.2020.08.002
U2 - 10.1016/bs.acc.2020.08.002
DO - 10.1016/bs.acc.2020.08.002
M3 - Chapter
SN - 9780128246146
VL - 102
T3 - Advances in Clinical Chemistry
SP - 192
EP - 232
BT - Advances in Clinical Chemistry
PB - Elsevier
ER -