Transient Abnormal Myelopoiesis Associated with Down Syndrome Presenting as Severe Hydrops Fetalis: A Case Report

Gemma Malin, Mark Kilby, M Velangi

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    We present a case of transient abnormal myelopoiesis (TAM) presenting as non-immune fetal hydrops (NIHF). Hydrops fetalis (HF) is a condition associated with very high perinatal mortality, especially when no treatable cause, such as fetal anaemia, exists. In fetuses prior to 24 weeks with NIHF, a chromosomal anomaly is a common association. TAM is a leukaemic condition, almost entirely limited to children with Down syndrome. The presentation of TAM prenatally is unusual but cases may present ultrasonographically with NIHF and associated fetal hepatosplenomegaly. We report a case presenting in this manner with NIHF detected at 29 weeks' gestation and discuss the subsequent diagnosis and management of in utero TAM. Copyright (C) 2010 S. Karger AG, Basel
    Original languageEnglish
    Pages (from-to)171-173
    Number of pages3
    JournalFetal Diagnosis and Therapy
    Volume27
    Issue number3
    DOIs
    Publication statusPublished - 1 Jan 2010

    Keywords

    • Down syndrome
    • Myelopoiesis, transient abnormal
    • Hydrops fetalis
    • Fetal hydrops, non-immune

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