Transforming growth factor-beta induces human T lymphocyte migration in vitro

D H Adams, M Hathaway, Jean Shaw, D Burnett, E Elias, A J Strain

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103 Citations (Scopus)


In addition to its activities as a growth factor, recent studies suggest an immunoregulatory role for transforming growth factor-beta (TGF-beta). In this context we have demonstrated that TGF-beta is a potent chemotactic factor in vitro for human T lymphocytes at a concentration of 40 fM and for monocytes at a concentration of 0.4 fM but that it has no chemotactic activity for neutrophils. Furthermore, using an assay of lymphocyte subset chemotaxis we have been able to show that TGF-beta can induce migration of both CD4+ and CD8+ T lymphocytes in vitro. This study provides further evidence that TGF-beta acts as a cytokine, being able to attract T lymphocytes and monocytes to sites of inflammation. Its role in the pathogenesis of inflammatory reactions is likely to be complex.

Original languageEnglish
Pages (from-to)609-12
Number of pages4
JournalJournal of Immunology
Issue number2
Publication statusPublished - 15 Jul 1991


  • Cells, Cultured
  • Chemotaxis, Leukocyte
  • Dose-Response Relationship, Drug
  • Humans
  • In Vitro Techniques
  • Monocytes
  • N-Formylmethionine Leucyl-Phenylalanine
  • Neutrophils
  • T-Lymphocytes
  • Transforming Growth Factor beta


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