Transcription-dependent silencing of inducible convergent transgenes in transgenic mice

Fernando J Calero-Nieto; Andrew G Bert; Peter N Cockerill

doi:10.1186/1756-8935-3-3

Transcription-dependent silencing of inducible convergent transgenes in transgenic mice

Fernando J Calero-Nieto, Andrew G Bert, Peter N Cockerill

Immunology and Immunotherapy

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Abstract

Silencing of transgenes in mice is a common phenomenon typically associated with short multi-copy transgenes. We have investigated the regulation of the highly inducible human granulocyte-macrophage colony-stimulating-factor gene (Csf2) in transgenic mice.

Original language	English
Number of pages	13
Journal	Epigenetics & Chromatin
Volume	3
Issue number	3
DOIs	https://doi.org/10.1186/1756-8935-3-3
Publication status	Published - 2010

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10.1186/1756-8935-3-3

Cockerill_et_al_Transcription-Dependent_silencing_Epigenetics_&_Chromatin_3_3_2010
Checked for eligibility: 4/12/15. © 2010 Calero-Nieto et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 0.98 MBLicence: Creative Commons: Attribution (CC BY)

Cite this

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title = "Transcription-dependent silencing of inducible convergent transgenes in transgenic mice",

abstract = "Silencing of transgenes in mice is a common phenomenon typically associated with short multi-copy transgenes. We have investigated the regulation of the highly inducible human granulocyte-macrophage colony-stimulating-factor gene (Csf2) in transgenic mice.",

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VL - 3

JO - Epigenetics & Chromatin

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Transcription-dependent silencing of inducible convergent transgenes in transgenic mice

Abstract

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