Transcription activation in bacteria: ancient and modern

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Regulatory interactions at the lac promoter.Activation of the transcription of genes is central to many processes of adaptation and differentiation in bacteria. Here, I review the molecular mechanisms by which transcription factors can activate the initiation of specific transcripts at bacterial promoters. The story is presented in the context of Marjory Stephenson's pioneering work on enzymatic adaptation in bacteria, and sets the different mechanisms in the greater context of how transcription regulatory mechanisms evolved.

Original languageEnglish
Pages (from-to)386-395
Number of pages10
Issue number4
Early online date18 Feb 2019
Publication statusPublished - 1 Apr 2019


  • Bacterial transcription
  • DNA-dependent RNA polymerase
  • activators
  • promoters


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