Tramtrack co-operates to prevent inappropriate neural development in Drosophila

Paul Badenhorst, John T Finch, Andrew A Travers

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Each sensory organ of the Drosophila peripheral nervous system is derived from a single sensory organ precursor cell (SOP). These originate in territories defined by expression of the proneural genes of the Achaete-Scute complex (AS-C). Formation of ectopic sensilla outside these regions is prevented by transcriptional repression of proneural genes. We demonstrate that the BTB/POZ-domain transcriptional repressor Tramtrack (Ttk) co-operates in this repression. Ttk is expressed ubiquitously, except in proneural clusters and SOPs. Ttk over-expression represses proneural genes and sensilla formation. Loss of Ttk enhances bristle-promoting mutants. Using neural repression as an assay, we dissected functional domains of Ttk, confirming the importance of the bric-à-brac-tramtrack-broad complex (BTB) motif. We show that the Ttk BTB domain is a protein-protein interaction motif mediating tetramer formation.

Original languageEnglish
Pages (from-to)87-101
Number of pages15
JournalMechanisms of Development
Issue number1-2
Publication statusPublished - Sept 2002

Bibliographical note

Copyright 2002 Elsevier Science Ireland Ltd.


  • Animals
  • Binding Sites
  • Drosophila
  • Drosophila Proteins
  • Female
  • Gene Expression Regulation, Developmental
  • Genes, Insect
  • Male
  • Mutagenesis
  • Peripheral Nerves
  • Protein Structure, Tertiary
  • Recombinant Fusion Proteins
  • Repressor Proteins
  • Sense Organs


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