Towards optimizing peptide-based inhibitors of protein-protein interactions: Predictive saturation variation scanning (PreSaVS)

Kristina Hetherington; Som Dutt; Amaurys A. Ibarra; Emma E. Cawood; Fruzsina Hobor; Derek N. Woolfson; Thomas A. Edwards; Adam Nelson; Richard B. Sessions; Andrew J. Wilson

doi:10.1039/d1cb00137j

Towards optimizing peptide-based inhibitors of protein-protein interactions: Predictive saturation variation scanning (PreSaVS)

Kristina Hetherington, Som Dutt, Amaurys A. Ibarra, Emma E. Cawood, Fruzsina Hobor, Derek N. Woolfson, Thomas A. Edwards, Adam Nelson, Richard B. Sessions^*, Andrew J. Wilson^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

22 Downloads (Pure)

Abstract

A simple-To-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein-protein interactions (PPIs) is described.

Original language	English
Pages (from-to)	1474-1478
Number of pages	5
Journal	RSC Chemical Biology
Volume	2
Issue number	5
Early online date	16 Aug 2021
DOIs	https://doi.org/10.1039/d1cb00137j
Publication status	Published - 1 Oct 2021

Bibliographical note

Funding Information:
This work was supported by EPSRC (EP/N013573/1 and EP/ KO39292/1) and the BBSRC/EPSRC-funded Synthetic Biology Research Centre, BrisSynBio (BB/L01386X/1). AN holds an EPSRC Established Career Fellowship (EP/N025652/1).

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus subject areas

Chemistry (miscellaneous)
Biochemistry
Molecular Biology
Biochemistry, Genetics and Molecular Biology (miscellaneous)

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10.1039/d1cb00137jLicence: Creative Commons: Attribution (CC BY)

HetheringtonK2021TowardsFinal published version, 2.56 MBLicence: Creative Commons: Attribution (CC BY)

Cite this

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title = "Towards optimizing peptide-based inhibitors of protein-protein interactions: Predictive saturation variation scanning (PreSaVS)",

abstract = "A simple-To-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein-protein interactions (PPIs) is described.",

author = "Kristina Hetherington and Som Dutt and Ibarra, \{Amaurys A.\} and Cawood, \{Emma E.\} and Fruzsina Hobor and Woolfson, \{Derek N.\} and Edwards, \{Thomas A.\} and Adam Nelson and Sessions, \{Richard B.\} and Wilson, \{Andrew J.\}",

note = "Funding Information: This work was supported by EPSRC (EP/N013573/1 and EP/ KO39292/1) and the BBSRC/EPSRC-funded Synthetic Biology Research Centre, BrisSynBio (BB/L01386X/1). AN holds an EPSRC Established Career Fellowship (EP/N025652/1). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2021",

month = oct,

day = "1",

doi = "10.1039/d1cb00137j",

language = "English",

volume = "2",

pages = "1474--1478",

journal = "RSC Chemical Biology",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Towards optimizing peptide-based inhibitors of protein-protein interactions

T2 - Predictive saturation variation scanning (PreSaVS)

AU - Hetherington, Kristina

AU - Dutt, Som

AU - Ibarra, Amaurys A.

AU - Cawood, Emma E.

AU - Hobor, Fruzsina

AU - Woolfson, Derek N.

AU - Edwards, Thomas A.

AU - Nelson, Adam

AU - Sessions, Richard B.

AU - Wilson, Andrew J.

N1 - Funding Information: This work was supported by EPSRC (EP/N013573/1 and EP/ KO39292/1) and the BBSRC/EPSRC-funded Synthetic Biology Research Centre, BrisSynBio (BB/L01386X/1). AN holds an EPSRC Established Career Fellowship (EP/N025652/1). Publisher Copyright: © The Royal Society of Chemistry.

PY - 2021/10/1

Y1 - 2021/10/1

N2 - A simple-To-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein-protein interactions (PPIs) is described.

AB - A simple-To-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein-protein interactions (PPIs) is described.

UR - https://www.scopus.com/pages/publications/85116928357

U2 - 10.1039/d1cb00137j

DO - 10.1039/d1cb00137j

M3 - Article

AN - SCOPUS:85116928357

SN - 2633-0679

VL - 2

SP - 1474

EP - 1478

JO - RSC Chemical Biology

JF - RSC Chemical Biology

IS - 5

ER -

Towards optimizing peptide-based inhibitors of protein-protein interactions: Predictive saturation variation scanning (PreSaVS)

Abstract

Bibliographical note

ASJC Scopus subject areas

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