Towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia and cortex

Daniele Caligiore, Giovanni Pezzulo, Gianluca Baldassarre, Andreea Bostan, Peter Strick, Kenji Doya, Rick Helmich, Michael Dark, James Houk, Henrik Jorntell, Angel Lago-Rodriguez, Joseph Galea, Rowland Miall, Traian Popa, Asha Kishore, Paul Verschure, Riccardo Zucca, Ivan Herreros

Research output: Contribution to journalArticlepeer-review

141 Citations (Scopus)
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Abstract

Despite increasing evidence suggesting the cerebellum works in concert with the cortex and basal ganglia, the nature of the reciprocal interactions between these three brain regions remains unclear. This consensus paper gathers diverse recent views on a variety of important roles played by the cerebellum within the cerebello-basal ganglia-thalamo-cortical system across a range of motor and cognitive functions. The paper includes theoretical and empirical contributions, which cover the following topics: recent evidence supporting the dynamical interplay between cerebellum, basal ganglia, and cortical areas in humans and other animals; theoretical neuroscience perspectives and empirical evidence on the reciprocal influences between cerebellum, basal ganglia, and cortex in learning and control processes; and data suggesting possible roles of the cerebellum in basal ganglia movement disorders. Although starting from different backgrounds and dealing with different topics, all the contributors agree that viewing the cerebellum, basal ganglia, and cortex as an integrated system enables us to understand the function of these areas in radically different ways. In addition, there is unanimous consensus between the authors that future experimental and computational work is needed to understand the function of cerebellar-basal ganglia circuitry in both motor and non-motor functions. The paper reports the most advanced perspectives on the role of the cerebellum within the cerebello-basal ganglia-thalamo-cortical system and illustrates other elements of consensus as well as disagreements and open questions in the field.
Original languageEnglish
Pages (from-to)203–229
JournalThe Cerebellum
Volume16
Issue number1
Early online date13 Feb 2016
DOIs
Publication statusPublished - Feb 2017

Keywords

  • Basal ganglia cerebellum anatomical link
  • Nucleo-olivary inhibition
  • Movement disorders
  • Parkinson’s disease tremor
  • Cerebellar motor and cognitive function
  • Non-invasive brain stimulation

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