Abstract
The recent Ebola and Zika epidemics demonstrate the need for the continuous surveillance, rapid diagnosis and real-time tracking of emerging infectious diseases. Fast, affordable sequencing of pathogen genomes - now a staple of the public health microbiology laboratory in well-resourced settings - can affect each of these areas. Coupling genomic diagnostics and epidemiology to innovative digital disease detection platforms raises the possibility of an open, global, digital pathogen surveillance system. When informed by a One Health approach, in which human, animal and environmental health are considered together, such a genomics-based system has profound potential to improve public health in settings lacking robust laboratory capacity.
| Original language | English |
|---|---|
| Pages (from-to) | 9-20 |
| Number of pages | 12 |
| Journal | Nature Reviews Genetics |
| Volume | 19 |
| Issue number | 1 |
| Early online date | 13 Nov 2017 |
| DOIs | |
| Publication status | Published - 1 Jan 2018 |
Keywords
- Animals
- Communicable Diseases, Emerging/epidemiology
- Computer Systems
- Environmental Health
- Epidemics
- Genomics
- Hemorrhagic Fever, Ebola/epidemiology
- High-Throughput Nucleotide Sequencing
- Humans
- Metagenomics
- Models, Biological
- Molecular Epidemiology
- Public Health
- Public Health Surveillance/methods
