Time and space resolved uptake study of silica nanoparticles by human cells

K. Shapero; F. Fenaroli; I. Lynch; A. Salvati; K.A. Dawson; D.C. Cottell

doi:10.1039/c0mb00109k

Time and space resolved uptake study of silica nanoparticles by human cells

K. Shapero, F. Fenaroli, I. Lynch, A. Salvati, K.A. Dawson, D.C. Cottell

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200 Citations (Scopus)

Abstract

A spatio-temporal mapping of the uptake of silica (SiO ) nanoparticles of different sizes by lung epithelial cells has been obtained. Based on high control of nanoparticle dispersion in cell media and cell exposure, one obtains reproducible and quantitative time-resolved data using a combination of flow cytometry, fluorescence and electron microscopies. We are thereby able to give a rather detailed account of the journey of SiO nanoparticles from the early events of uptake to their final sub-cellular localization.

Original language	English
Pages (from-to)	371-378
Number of pages	8
Journal	Molecular BioSystems
Volume	7
Issue number	2
DOIs	https://doi.org/10.1039/c0mb00109k
Publication status	Published - 1 Feb 2011

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AU - Fenaroli, F.

AU - Lynch, I.

AU - Salvati, A.

AU - Dawson, K.A.

AU - Cottell, D.C.

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AB - A spatio-temporal mapping of the uptake of silica (SiO ) nanoparticles of different sizes by lung epithelial cells has been obtained. Based on high control of nanoparticle dispersion in cell media and cell exposure, one obtains reproducible and quantitative time-resolved data using a combination of flow cytometry, fluorescence and electron microscopies. We are thereby able to give a rather detailed account of the journey of SiO nanoparticles from the early events of uptake to their final sub-cellular localization.

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Time and space resolved uptake study of silica nanoparticles by human cells

Abstract

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