Thyroid hormone responsiveness in N-Tera-2 cells

Shiao-yng Chan, Christopher McCabe, TJ Visser, Jayne Franklyn, Mark Kilby

Research output: Contribution to journalArticle

10 Citations (Scopus)


N-TERA-2 cl/D1 (NT2) cells, a human embryonal cell line with characteristics of central nervous system precursor cells, were utilised to study thyroid hormone action during early neuronal growth and differentiation. Undifferentiated NT2 cells expressed mRNAs encoding thyroid hormone receptors (TRs) alpha1, alpha2 and beta1, iodothyronine deiodinases types 2 (D2) and 3 (D3) (which act as the pre-receptor regulators), and the thyroid hormone-responsive genes myelin basic protein (MBP) and neuroendocrine specific protein A (NSP-A). When terminally differentiated into post-mitotic neurons (hNT), TRalpha1 and TRbeta1 mRNA expression was decreased by 74% (P=0.05) and 95% (P
Original languageEnglish
Pages (from-to)159-67
Number of pages9
JournalJournal of Endocrinology
Issue number1
Publication statusPublished - 1 Jul 2003


Dive into the research topics of 'Thyroid hormone responsiveness in N-Tera-2 cells'. Together they form a unique fingerprint.

Cite this