Thrombogenesis and endothelial damage/dysfunction in peripheral artery disease. Relationship to ethnicity and disease severity

Andrew Makin, Natali Chung, Stanley Silverman, Gregory Lip

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Peripheral artery disease (PAD) and intermittent claudication are common in men aged over 55 years. Once the diagnosis has been made, very few patients suffer from a deterioration of the disease. Those that do deteriorate tend to do so due to thrombosis of an affected artery. It is apparent that the disruption in the vessel wall accounts for some of the cause of the thrombosis but blood constituents also play a role. We hypothesized that levels of soluble P-selectin (sP-sel, a marker of platelet activation), von Willebrand factor (vWf, an index of endothelial damage/dysfunction), tissue factor (TF, a coagulation protein involved in the 'extrinsic' coagulation pathway) and fibrinogen would be abnormally elevated in relation to disease severity and correlated with each other, and related to ethnicity, in a multiethnic population of patients with PAD. To test this hypothesis, we studied 234 patients (80% white, 7% Indo-Asian, 13% Afro-Caribbean) with confirmed PAD [ankle brachial pressure index (ABPI)<or =0.8] and 50 healthy controls. All of the indices studied were increased in patients over controls (p
Original languageEnglish
Pages (from-to)221-216
Number of pages6
JournalThrombosis Research
Volume111
Issue number4-5
DOIs
Publication statusPublished - 1 Jan 2003

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