Three-dimensional time-resolved optical tomography of a conical breast phantom

Jeremy C. Hebden; Hylke Veenstra; Hamid Dehghani; Elizabeth M.C. Hillman; Martin Schweiger; Simon R. Arridge; David T. Delpy

doi:10.1364/AO.40.003278

Three-dimensional time-resolved optical tomography of a conical breast phantom

Jeremy C. Hebden
, Hylke Veenstra
, Hamid Dehghani
, Elizabeth M.C. Hillman
, Martin Schweiger
, Simon R. Arridge
, David T. Delpy

Computer Science

Research output: Contribution to journal › Article › peer-review

Abstract

A 32-channel time-resolved imaging device for medical optical tomography has been employed to evaluate a scheme for imaging the human female breast. The fully automated instrument and the reconstruction procedure have been tested on a conical phantom with tissue-equivalent optical properties. The imaging protocol has been designed to obviate compression of the breast and the need for coupling fluids. Images are generated from experimental data with an iterative reconstruction algorithm that employs a threedimensional (3D) finite-element diffusion-based forward model. Embedded regions with twice the background optical properties are revealed in separate 3D absorption and scattering images of the phantom. The implications for 3D time-resolved optical tomography of the breast are discussed.

Original language	English
Pages (from-to)	3278-3287
Number of pages	10
Journal	Applied Optics
Volume	40
Issue number	19
DOIs	https://doi.org/10.1364/AO.40.003278
Publication status	Published - 1 Jul 2001

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Engineering (miscellaneous)
Electrical and Electronic Engineering

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10.1364/AO.40.003278

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title = "Three-dimensional time-resolved optical tomography of a conical breast phantom",

abstract = "A 32-channel time-resolved imaging device for medical optical tomography has been employed to evaluate a scheme for imaging the human female breast. The fully automated instrument and the reconstruction procedure have been tested on a conical phantom with tissue-equivalent optical properties. The imaging protocol has been designed to obviate compression of the breast and the need for coupling fluids. Images are generated from experimental data with an iterative reconstruction algorithm that employs a threedimensional (3D) finite-element diffusion-based forward model. Embedded regions with twice the background optical properties are revealed in separate 3D absorption and scattering images of the phantom. The implications for 3D time-resolved optical tomography of the breast are discussed.",

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AU - Veenstra, Hylke

AU - Dehghani, Hamid

AU - Hillman, Elizabeth M.C.

AU - Schweiger, Martin

AU - Arridge, Simon R.

AU - Delpy, David T.

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Three-dimensional time-resolved optical tomography of a conical breast phantom

Abstract

ASJC Scopus subject areas

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