Thermosensitive hydrogel as an in situ gelling antimicrobial ocular dressing

Sameed Mohammed, Gurpreet Chouhan, Olachi Anuforom, Megan Cooke, Anna Walsh, Peter Morgan-Warren, Michael Jenkins, Felicity De Cogan

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)
366 Downloads (Pure)


Microbial keratitis is a severe ocular condition and one of the most prevalent causes of corneal scarring and associated blindness worldwide. Risk factors include contact lens use, ocular trauma, ocular surface disease and immunosuppression. Initial clinical management mandates intensive (hourly or more frequent) topical administration of broad spectrum antimicrobial therapy for at least 48 h, which may require hospital admission, followed by tailored therapy based on microbiological investigation and the institution of strategies to reduce inflammation and promote healing. In this work we report an ocular wound dressing which can encapsulate and give sustained release of different antibiotics. The use of this dressing would allow patients to have eye drops
on a 4 hourly basis, thereby facilitating treatment compliance and reducing hospital admissions.
Original languageEnglish
Pages (from-to)203-209
Number of pages7
JournalMaterials Science and Engineering C
Early online date12 Apr 2017
Publication statusPublished - 1 Sept 2017


  • Wound dressing
  • Hydrogel
  • Antibiotic delivery
  • Ocular drug delivery


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