Thermo-Responsive Actuation of a DNA Origami Flexor

Vladimir A. Turek, Rohit Chikkaraddy, Sean Cormier, Bill Stockham, Tao Ding, Ulrich F. Keyser, Jeremy J. Baumberg

Research output: Contribution to journalArticlepeer-review


Nanomachines capable of controlled programmable work at the nanoscale promise to revolutionize a vast range of research and eventually should impact on daily lives. Due to the ease of design and modification, DNA origami is emerging as a natural platform to build such machines. However, one essential challenge is the controlled and rapid actuation of DNA origami using an external biocompatible stimulus. Here, actuation based on temperature-induced phase transitions of the thermo-responsive polymer poly(N-isopropylacrylamide) (PNIPAM) is reported. By incorporating this polymer into DNA origami structures on either side of a flexible region, a “DNA origami flexor” is created that uses the tunable PNIPAM hydrophobicity to reversibly open and close the DNA structures. Such a mechanism has the advantage of being versatile and biocompatible, and possessing strong response to temperature changes of a few degrees Kelvin.
Original languageEnglish
Article number1706410
JournalAdvanced Functional Materials
Issue number25
Publication statusPublished - 8 Mar 2018


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