Therapies in ALS - beyond Riluzole

Karen Morrison

    Research output: Contribution to journalArticle

    27 Citations (Scopus)


    Several mechanisms have been proposed to account for the progressive motor neurone death evident in amyotrophic lateral sclerosis. These include oxidative stress, neurofilament damage, mitochondrial abnormalities, glutamate-mediated excitotoxicity and altered responses to hypoxia. Current quests for therapies involve studying combinations of agents that act by various mechanisms and evaluating stem-cell therapies in model systems. High-throughput cell-culture screening systems are also being developed. The goal for therapy is to define agents that clearly prevent progression of, and it is hoped even reverse, motor neurone loss.
    Original languageEnglish
    Pages (from-to)302-309
    Number of pages8
    JournalCurrent Opinion in Pharmacology
    Issue number3
    Publication statusPublished - 1 Jun 2002


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