TY - JOUR
T1 - Therapies in ALS - beyond Riluzole
AU - Morrison, Karen
PY - 2002/6/1
Y1 - 2002/6/1
N2 - Several mechanisms have been proposed to account for the progressive motor neurone death evident in amyotrophic lateral sclerosis. These include oxidative stress, neurofilament damage, mitochondrial abnormalities, glutamate-mediated excitotoxicity and altered responses to hypoxia. Current quests for therapies involve studying combinations of agents that act by various mechanisms and evaluating stem-cell therapies in model systems. High-throughput cell-culture screening systems are also being developed. The goal for therapy is to define agents that clearly prevent progression of, and it is hoped even reverse, motor neurone loss.
AB - Several mechanisms have been proposed to account for the progressive motor neurone death evident in amyotrophic lateral sclerosis. These include oxidative stress, neurofilament damage, mitochondrial abnormalities, glutamate-mediated excitotoxicity and altered responses to hypoxia. Current quests for therapies involve studying combinations of agents that act by various mechanisms and evaluating stem-cell therapies in model systems. High-throughput cell-culture screening systems are also being developed. The goal for therapy is to define agents that clearly prevent progression of, and it is hoped even reverse, motor neurone loss.
UR - http://www.scopus.com/inward/record.url?scp=0036605466&partnerID=8YFLogxK
U2 - 10.1016/S1471-4892(02)00169-8
DO - 10.1016/S1471-4892(02)00169-8
M3 - Article
C2 - 12020475
VL - 2
SP - 302
EP - 309
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
IS - 3
ER -