The zebrafish (Danio rerio) model in toxicity testing

Stephanie Padilla; Scott Glaberman

doi:10.1016/B978-0-12-813602-7.00037-5

The zebrafish (Danio rerio) model in toxicity testing

Stephanie Padilla, Scott Glaberman

Biosciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Zebrafish have become a popular model for both human and ecological toxicity assessments. This chapter discusses the scientific reasons for that popularity; describing many examples of similarities between zebrafish and mammalian function and development; how zebrafish have been used to discover novel pathways or mechanisms of toxicity; and the use of zebrafish as a model for ecological risk assessment, especially for rapid hazard testing and as bridge between laboratory and field-based studies. As toxicologists and regulators begin to recognize that there are many parallels between zebrafish and other vertebrate organisms, the use of zebrafish in both human and ecological toxicity assessments will become more common.

Original language	English
Title of host publication	An Introduction to Interdisciplinary Toxicology
Subtitle of host publication	From Molecules to Man
Publisher	Elsevier Korea
Pages	525-532
Number of pages	8
ISBN (Electronic)	9780128136027
ISBN (Print)	9780128136034
DOIs	https://doi.org/10.1016/B978-0-12-813602-7.00037-5
Publication status	Published - 1 Jan 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc. All rights reserved.

Keywords

ecotoxicity
hazard testing
internal dose
mechanism of toxicity
toxicity assessment: human health
Zebrafish

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-813602-7.00037-5

Cite this

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ER -

The zebrafish (Danio rerio) model in toxicity testing

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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