Projects per year
Arp2/3 complex nucleates the formation of dendritic actin filament arrays, which are especially prominent at the leading edges of motile cells. Recent genetic and other loss-of-function studies have highlighted the importance of the Arp2/3 complex for normal cell functions, and especially for cell motility. WASP/Scar family proteins regulate the activity of the Arp2/3 complex, and also link it to several signaling pathways. Recent studies suggest that Scar is a more important regulator of Arp2/3 activity in actin-dependent morphological processes than WASP, which may have a more restricted role in specialized cellular events. It has also become clear that precise regulation of both Scar and WASP activity is of the utmost importance for their physiological functions.
|Number of pages||8|
|Journal||Current Opinion in Cell Biology|
|Publication status||Published - 1 Jan 2004|
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- 1 Finished
Fellowship: Dr L Machesky - The Arp2/3 Complex in Actin- Based Motility.
1/10/00 → 30/09/05
Project: Research Councils