The WASP-Arp2/3 pathway: genetic insights

Maria Vartiainen, Laura Machesky

Research output: Contribution to journalReview article

77 Citations (Scopus)


Arp2/3 complex nucleates the formation of dendritic actin filament arrays, which are especially prominent at the leading edges of motile cells. Recent genetic and other loss-of-function studies have highlighted the importance of the Arp2/3 complex for normal cell functions, and especially for cell motility. WASP/Scar family proteins regulate the activity of the Arp2/3 complex, and also link it to several signaling pathways. Recent studies suggest that Scar is a more important regulator of Arp2/3 activity in actin-dependent morphological processes than WASP, which may have a more restricted role in specialized cellular events. It has also become clear that precise regulation of both Scar and WASP activity is of the utmost importance for their physiological functions.
Original languageEnglish
Pages (from-to)174-181
Number of pages8
JournalCurrent Opinion in Cell Biology
Publication statusPublished - 1 Jan 2004


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