The value of histopathological examination of salivary gland biopsies in diagnosis, prognosis and treatment of Sjögren's Syndrome

Francesca Barone, Joana Campos, Simon Bowman, Benjamin A Fisher

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)
110 Downloads (Pure)

Abstract

Primary Sjögren's syndrome (pSS) is a complex autoimmune disease characterised by local exocrine glandular involvement and systemic multiorgan manifestations. In this review we will discuss the value of the histological examination of the salivary glands in the classification criteria, and more recently as prognostic tool for patient stratification and monitoring. The limitations of the current tools used to assess salivary gland pathology in pSS will also be reviewed in relation to using salivary gland biopsy analysis as an outcome measure in clinical trials.

Original languageEnglish
Article numberw14168
Number of pages11
JournalSwiss medical weekly
Volume145
DOIs
Publication statusPublished - 7 Sept 2015

Keywords

  • Biopsy
  • Humans
  • Predictive Value of Tests
  • Prognosis
  • Salivary Glands
  • Sjogren's Syndrome
  • salivary gland biopsy
  • histology
  • germinal centers
  • biologics
  • outcome measures

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