The vaccination model in psychoneuroimmunology research: A review

Anna C. Whittaker*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

4 Citations (Scopus)


This chapter explores the reasoning behind using the vaccination model to examine the influence of psychosocial factors on immunity. It then briefly discusses the mechanics of the vaccination response and the protocols used in psychoneuroimmunology vaccine research, before giving examples from the research literature of the studies examining relationships such as the association between stress and vaccination response. It also explores the ways the vaccination model can be used to answer key questions in psychoneuroimmunology, such as the following: “Does it matter when stressful life events occur relative to when the vaccine is received?” “What are the effects of prior exposure to the antigen?” “Do other psychosocial factors influence vaccine response besides stress?” Finally, it briefly considers the mechanisms underlying psychosocial factors and vaccination response associations and the future research needed to understand these better, and indeed to use current and future knowledge to improve and enhance vaccine responses in key at-risk populations.

Original languageEnglish
Title of host publicationPsychoneuroimmunology
Subtitle of host publicationMethods and Protocols
EditorsQing Yan
PublisherHumana Press
Number of pages18
ISBN (Electronic)978-1-4939-7828-1
ISBN (Print)978-1-4939-7827-4
Publication statusPublished - 29 Apr 2018

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Caregiving
  • Influenza
  • Interventions
  • Social support
  • Stress
  • Vaccine

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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