The two faces of BRCA2, a FANCtastic discovery

Grant Stewart, SJ Elledge

Research output: Contribution to journalArticle

28 Citations (Scopus)


The molecular defects responsible for the cancer predisposition syndrome Fanconi's Anemia (FA) have been elusive. A recent study reports that the FANC-B and -D1 subgroups result from hypomorphic mutations in BRCA2. Given that BRCA2 protein participates in homologous recombination, this finding connects at least a subset of the FA phenotypes to defective DNA repair.
Original languageEnglish
Pages (from-to)2-4
Number of pages3
JournalMolecular Cell
Publication statusPublished - 1 Jul 2002


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