The transcriptome of enterohaemorrhagic Escherichia coli O157 adhering to eukaryotic plasma membranes

S Dahan, Stuart Knutton, Robert Shaw, VF Crepin, G Dougan, G Frankel

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Using a DNA microarray, we determined changes in enterohemorrhagic Escherichia coli O157:H7 gene expression during binding to plasma membranes. Analysis of the complete transcriptomes of the bound bacteria revealed increased levels of stress-associated mRNAs and decreased levels of mRNA encoding proteins involved in translation and type III secretion.
Original languageEnglish
Pages (from-to)5452-5459
Number of pages8
JournalInfection and Immunity
Volume72
DOIs
Publication statusPublished - 1 Jan 2004

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