The temporal signature of memories: identification of a general mechanism for dynamic memory replay in humans

Sebastian Michelmann; Howard Bowman; Simon Hanslmayr

doi:10.1371/journal.pbio.1002528

The temporal signature of memories: identification of a general mechanism for dynamic memory replay in humans

Sebastian Michelmann, Howard Bowman, Simon Hanslmayr

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Abstract

Reinstatement of dynamic memories requires the replay of neural patterns that unfold over time in a similar manner as during perception. However, little is known about the mechanisms that guide such a temporally structured replay in humans, because previous studies
used either unsuitable methods or paradigms to address this question. Here, we overcome these limitations by developing a new analysis method to detect the replay of temporal patterns in a paradigm that requires participants to mentally replay short sound or video clips.
We show that memory reinstatement is accompanied by a decrease of low-frequency (8 Hz) power, which carries a temporal phase signature of the replayed stimulus. These replay effects were evident in the visual as well as in the auditory domain and were localized to sensory-specific regions. These results suggest low-frequency phase to be a domain-general mechanism that orchestrates dynamic memory replay in humans.

Original language	English
Article number	e1002528
Journal	PLoS Biology
Volume	14
Issue number	8
DOIs	https://doi.org/10.1371/journal.pbio.1002528
Publication status	Published - 5 Aug 2016

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10.1371/journal.pbio.1002528Licence: Creative Commons: Attribution (CC BY)

MichelmannS2016Temporal
Checked for eligibility: 12/08/2016. © 2016 Michelmann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Final published version, 5.56 MBLicence: Creative Commons: Attribution (CC BY)

https://doi.org/10.1371/journal.pbio.1002528Licence: Creative Commons: Attribution (CC BY)

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abstract = "Reinstatement of dynamic memories requires the replay of neural patterns that unfold over time in a similar manner as during perception. However, little is known about the mechanisms that guide such a temporally structured replay in humans, because previous studiesused either unsuitable methods or paradigms to address this question. Here, we overcome these limitations by developing a new analysis method to detect the replay of temporal patterns in a paradigm that requires participants to mentally replay short sound or video clips.We show that memory reinstatement is accompanied by a decrease of low-frequency (8 Hz) power, which carries a temporal phase signature of the replayed stimulus. These replay effects were evident in the visual as well as in the auditory domain and were localized to sensory-specific regions. These results suggest low-frequency phase to be a domain-general mechanism that orchestrates dynamic memory replay in humans.",

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The temporal signature of memories: identification of a general mechanism for dynamic memory replay in humans

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