The t(14;20) is a poor prognostic factor in myeloma but is associated with long-term stable disease in monoclonal gammopathies of undetermined significance

FM Ross; L Chiecchio; G Dagrada; RKM Protheroe; DM Stockley; CJ Harrison; NCP Cross; AJ Szubert; Mark Drayson; GJ Morgan

doi:10.3324/haematol.2009.016329

The t(14;20) is a poor prognostic factor in myeloma but is associated with long-term stable disease in monoclonal gammopathies of undetermined significance

FM Ross
, L Chiecchio
, G Dagrada
, RKM Protheroe
, DM Stockley
, CJ Harrison
, NCP Cross
, AJ Szubert
, Mark Drayson
, GJ Morgan

Immunology and Immunotherapy

Research output: Contribution to journal › Article

63 Citations (Scopus)

Abstract

A large series of plasma cell dyscrasias (n=2207) was examined for translocations which deregulate the MAF genes, t(14;20)(q32;q12) and t(14;16)(q32;q23), and their disease behavior was compared to a group characterized by the t(4;14)(p16;q32) where CCND2 is also up-regulated. The t(14;20) showed low prevalence in myeloma (27/1830, 1.5%) and smoldering myeloma (1/148,

Original language	English
Pages (from-to)	1221-1225
Number of pages	5
Journal	Haematologica
Volume	95
Issue number	7
DOIs	https://doi.org/10.3324/haematol.2009.016329
Publication status	Published - 1 Jul 2010

Keywords

myeloma
chromosome abnormality
plasma cell
disease progression
MGUS

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10.3324/haematol.2009.016329

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Ross, FM., Chiecchio, L., Dagrada, G., Protheroe, RKM., Stockley, DM., Harrison, CJ., Cross, NCP., Szubert, AJ., Drayson, M., & Morgan, GJ. (2010). The t(14;20) is a poor prognostic factor in myeloma but is associated with long-term stable disease in monoclonal gammopathies of undetermined significance. Haematologica, 95(7), 1221-1225. https://doi.org/10.3324/haematol.2009.016329

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abstract = "A large series of plasma cell dyscrasias (n=2207) was examined for translocations which deregulate the MAF genes, t(14;20)(q32;q12) and t(14;16)(q32;q23), and their disease behavior was compared to a group characterized by the t(4;14)(p16;q32) where CCND2 is also up-regulated. The t(14;20) showed low prevalence in myeloma (27/1830, 1.5\%) and smoldering myeloma (1/148, ",

keywords = "myeloma, chromosome abnormality, plasma cell, disease progression, MGUS",

author = "FM Ross and L Chiecchio and G Dagrada and RKM Protheroe and DM Stockley and CJ Harrison and NCP Cross and AJ Szubert and Mark Drayson and GJ Morgan",

year = "2010",

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doi = "10.3324/haematol.2009.016329",

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Ross, FM, Chiecchio, L, Dagrada, G, Protheroe, RKM, Stockley, DM, Harrison, CJ, Cross, NCP, Szubert, AJ, Drayson, M & Morgan, GJ 2010, 'The t(14;20) is a poor prognostic factor in myeloma but is associated with long-term stable disease in monoclonal gammopathies of undetermined significance', Haematologica, vol. 95, no. 7, pp. 1221-1225. https://doi.org/10.3324/haematol.2009.016329

TY - JOUR

T1 - The t(14;20) is a poor prognostic factor in myeloma but is associated with long-term stable disease in monoclonal gammopathies of undetermined significance

AU - Ross, FM

AU - Chiecchio, L

AU - Dagrada, G

AU - Protheroe, RKM

AU - Stockley, DM

AU - Harrison, CJ

AU - Cross, NCP

AU - Szubert, AJ

AU - Drayson, Mark

AU - Morgan, GJ

PY - 2010/7/1

Y1 - 2010/7/1

N2 - A large series of plasma cell dyscrasias (n=2207) was examined for translocations which deregulate the MAF genes, t(14;20)(q32;q12) and t(14;16)(q32;q23), and their disease behavior was compared to a group characterized by the t(4;14)(p16;q32) where CCND2 is also up-regulated. The t(14;20) showed low prevalence in myeloma (27/1830, 1.5%) and smoldering myeloma (1/148,

AB - A large series of plasma cell dyscrasias (n=2207) was examined for translocations which deregulate the MAF genes, t(14;20)(q32;q12) and t(14;16)(q32;q23), and their disease behavior was compared to a group characterized by the t(4;14)(p16;q32) where CCND2 is also up-regulated. The t(14;20) showed low prevalence in myeloma (27/1830, 1.5%) and smoldering myeloma (1/148,

KW - myeloma

KW - chromosome abnormality

KW - plasma cell

KW - disease progression

KW - MGUS

U2 - 10.3324/haematol.2009.016329

DO - 10.3324/haematol.2009.016329

M3 - Article

C2 - 20410185

SN - 1592-8721

VL - 95

SP - 1221

EP - 1225

JO - Haematologica

JF - Haematologica

IS - 7

ER -

The t(14;20) is a poor prognostic factor in myeloma but is associated with long-term stable disease in monoclonal gammopathies of undetermined significance

Abstract

Keywords

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