The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas

J Chen; W-O Lui; MD Vos; GJ Clark; M Takahashi; J Schoumans; SK Khoo; D Petillo; T Lavery; J Sugimura; Dewi Astuti; C Zhang; S Kagawa; Eamonn Maher; C Larsson; AS Alberts; H Kanayama; BT Teh

doi:10.1016/S1535-6108(03)00269-1

The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas

J Chen
, W-O Lui
, MD Vos
, GJ Clark
, M Takahashi
, J Schoumans
, SK Khoo
, D Petillo
, T Lavery
, J Sugimura
, Dewi Astuti
, C Zhang
, S Kagawa
, Eamonn Maher
, C Larsson
, AS Alberts
, H Kanayama
, BT Teh

Research output: Contribution to journal › Article

87 Citations (Scopus)

Abstract

By positional cloning, we identified two breakpoint-spanning genes in a familial clear cell renal cell carcinoma (CCRCC)-associated t(1;3)(q32.1;q13.3): LSAMP and NORE1 (RASSF1 homolog). Both genes are downregulated in 9 of 9 RCC cell lines. While the NORE1A promoter predominantly presents partial methylation in 6 of the cell lines and 17/53 (32%) primary tumors, the LSAMP promoter is completely methylated in 5 of 9 cell lines and in 14/53 (26%) sporadic and 4 familial CCRCCs. Expression of LSAMP and NORE1A proteins in CCRCC cell lines inhibited cell proliferation. These characteristics indicate that LSAMP and NORE1A may represent new candidate tumor suppressors for CCRCC.

Original language	English
Pages (from-to)	405-413
Number of pages	9
Journal	Cancer Cell
Volume	4
Issue number	5
DOIs	https://doi.org/10.1016/S1535-6108(03)00269-1
Publication status	Published - 1 Nov 2003

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Chen, J., Lui, W.-O., Vos, MD., Clark, GJ., Takahashi, M., Schoumans, J., Khoo, SK., Petillo, D., Lavery, T., Sugimura, J., Astuti, D., Zhang, C., Kagawa, S., Maher, E., Larsson, C., Alberts, AS., Kanayama, H., & Teh, BT. (2003). The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas. Cancer Cell, 4(5), 405-413. https://doi.org/10.1016/S1535-6108(03)00269-1

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title = "The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas",

abstract = "By positional cloning, we identified two breakpoint-spanning genes in a familial clear cell renal cell carcinoma (CCRCC)-associated t(1;3)(q32.1;q13.3): LSAMP and NORE1 (RASSF1 homolog). Both genes are downregulated in 9 of 9 RCC cell lines. While the NORE1A promoter predominantly presents partial methylation in 6 of the cell lines and 17/53 (32\%) primary tumors, the LSAMP promoter is completely methylated in 5 of 9 cell lines and in 14/53 (26\%) sporadic and 4 familial CCRCCs. Expression of LSAMP and NORE1A proteins in CCRCC cell lines inhibited cell proliferation. These characteristics indicate that LSAMP and NORE1A may represent new candidate tumor suppressors for CCRCC.",

author = "J Chen and W-O Lui and MD Vos and GJ Clark and M Takahashi and J Schoumans and SK Khoo and D Petillo and T Lavery and J Sugimura and Dewi Astuti and C Zhang and S Kagawa and Eamonn Maher and C Larsson and AS Alberts and H Kanayama and BT Teh",

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month = nov,

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doi = "10.1016/S1535-6108(03)00269-1",

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Chen, J, Lui, W-O, Vos, MD, Clark, GJ, Takahashi, M, Schoumans, J, Khoo, SK, Petillo, D, Lavery, T, Sugimura, J, Astuti, D, Zhang, C, Kagawa, S, Maher, E, Larsson, C, Alberts, AS, Kanayama, H & Teh, BT 2003, 'The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas', Cancer Cell, vol. 4, no. 5, pp. 405-413. https://doi.org/10.1016/S1535-6108(03)00269-1

TY - JOUR

T1 - The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas

AU - Chen, J

AU - Lui, W-O

AU - Vos, MD

AU - Clark, GJ

AU - Takahashi, M

AU - Schoumans, J

AU - Khoo, SK

AU - Petillo, D

AU - Lavery, T

AU - Sugimura, J

AU - Astuti, Dewi

AU - Zhang, C

AU - Kagawa, S

AU - Maher, Eamonn

AU - Larsson, C

AU - Alberts, AS

AU - Kanayama, H

AU - Teh, BT

PY - 2003/11/1

Y1 - 2003/11/1

N2 - By positional cloning, we identified two breakpoint-spanning genes in a familial clear cell renal cell carcinoma (CCRCC)-associated t(1;3)(q32.1;q13.3): LSAMP and NORE1 (RASSF1 homolog). Both genes are downregulated in 9 of 9 RCC cell lines. While the NORE1A promoter predominantly presents partial methylation in 6 of the cell lines and 17/53 (32%) primary tumors, the LSAMP promoter is completely methylated in 5 of 9 cell lines and in 14/53 (26%) sporadic and 4 familial CCRCCs. Expression of LSAMP and NORE1A proteins in CCRCC cell lines inhibited cell proliferation. These characteristics indicate that LSAMP and NORE1A may represent new candidate tumor suppressors for CCRCC.

AB - By positional cloning, we identified two breakpoint-spanning genes in a familial clear cell renal cell carcinoma (CCRCC)-associated t(1;3)(q32.1;q13.3): LSAMP and NORE1 (RASSF1 homolog). Both genes are downregulated in 9 of 9 RCC cell lines. While the NORE1A promoter predominantly presents partial methylation in 6 of the cell lines and 17/53 (32%) primary tumors, the LSAMP promoter is completely methylated in 5 of 9 cell lines and in 14/53 (26%) sporadic and 4 familial CCRCCs. Expression of LSAMP and NORE1A proteins in CCRCC cell lines inhibited cell proliferation. These characteristics indicate that LSAMP and NORE1A may represent new candidate tumor suppressors for CCRCC.

UR - https://www.scopus.com/pages/publications/10744226004

U2 - 10.1016/S1535-6108(03)00269-1

DO - 10.1016/S1535-6108(03)00269-1

M3 - Article

C2 - 14667507

VL - 4

SP - 405

EP - 413

JO - Cancer Cell

JF - Cancer Cell

IS - 5

ER -

The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas

Abstract

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