The T cell response to persistent herpes virus infections in common variable

M Raeiszadeh, J Kopycinski, SJ Paston, T Diss, M Lowdell, GAD Hardy, Andrew Hislop, S Workman, A Dodi, V Emery, AD Webster

Research output: Contribution to journalArticle

49 Citations (Scopus)


We show that at least half of patients with common variable immunodeficiency (CVID) have circulating CD8(+) T cells specific for epitopes derived from cytomegalovirus (CMV) and/or the Epstein-Barr virus (EBV). Compared to healthy age-matched subjects, more CD8(+) T cells in CVID patients were committed to CMV. Despite previous reports of defects in antigen presentation and cellular immunity in CVID, specific CD4(+) and CD8(+) T cells produced interferon (IFN)-gamma after stimulation with CMV peptides, and peripheral blood mononuclear cells secreted perforin in response to these antigens. In CVID patients we found an association between a high percentage of circulating CD8(+) CD57(+) T cells containing perforin, CMV infection and a low CD4/CD8 ratio, suggesting that CMV may have a major role in the T cell abnormalities described previously in this disease. We also show preliminary evidence that CMV contributes to the previously unexplained severe enteropathy that occurs in about 5% of patients.
Original languageEnglish
Pages (from-to)234-242
Number of pages9
JournalClinical & Experimental Immunology
Publication statusPublished - 1 Nov 2006


  • common variable immunodeficiency
  • perforin
  • CD8+T lymphocytes
  • cytomegalovirus


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