TY - JOUR
T1 - The T cell response to persistent herpes virus infections in common variable
AU - Raeiszadeh, M
AU - Kopycinski, J
AU - Paston, SJ
AU - Diss, T
AU - Lowdell, M
AU - Hardy, GAD
AU - Hislop, Andrew
AU - Workman, S
AU - Dodi, A
AU - Emery, V
AU - Webster, AD
PY - 2006/11/1
Y1 - 2006/11/1
N2 - We show that at least half of patients with common variable immunodeficiency (CVID) have circulating CD8(+) T cells specific for epitopes derived from cytomegalovirus (CMV) and/or the Epstein-Barr virus (EBV). Compared to healthy age-matched subjects, more CD8(+) T cells in CVID patients were committed to CMV. Despite previous reports of defects in antigen presentation and cellular immunity in CVID, specific CD4(+) and CD8(+) T cells produced interferon (IFN)-gamma after stimulation with CMV peptides, and peripheral blood mononuclear cells secreted perforin in response to these antigens. In CVID patients we found an association between a high percentage of circulating CD8(+) CD57(+) T cells containing perforin, CMV infection and a low CD4/CD8 ratio, suggesting that CMV may have a major role in the T cell abnormalities described previously in this disease. We also show preliminary evidence that CMV contributes to the previously unexplained severe enteropathy that occurs in about 5% of patients.
AB - We show that at least half of patients with common variable immunodeficiency (CVID) have circulating CD8(+) T cells specific for epitopes derived from cytomegalovirus (CMV) and/or the Epstein-Barr virus (EBV). Compared to healthy age-matched subjects, more CD8(+) T cells in CVID patients were committed to CMV. Despite previous reports of defects in antigen presentation and cellular immunity in CVID, specific CD4(+) and CD8(+) T cells produced interferon (IFN)-gamma after stimulation with CMV peptides, and peripheral blood mononuclear cells secreted perforin in response to these antigens. In CVID patients we found an association between a high percentage of circulating CD8(+) CD57(+) T cells containing perforin, CMV infection and a low CD4/CD8 ratio, suggesting that CMV may have a major role in the T cell abnormalities described previously in this disease. We also show preliminary evidence that CMV contributes to the previously unexplained severe enteropathy that occurs in about 5% of patients.
KW - common variable immunodeficiency
KW - perforin
KW - CD8+T lymphocytes
KW - cytomegalovirus
UR - http://www.scopus.com/inward/record.url?scp=33750070624&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2249.2006.03209.x
DO - 10.1111/j.1365-2249.2006.03209.x
M3 - Article
C2 - 17034575
SN - 0009-9104
VL - 146
SP - 234
EP - 242
JO - Clinical & Experimental Immunology
JF - Clinical & Experimental Immunology
ER -