The T-cell response to haptenated insulins. II. The antibody response

M Flory, G R Wallace, K Oettel, B M Chain

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


As described in an accompanying paper, trinitrophenyl (TNP) modification of pork insulin (PI) at the A1 glycine position allows this molecule to stimulate a proliferative response in H-2b (B10) mice. We now show that this antigen stimulates low IgG responses in the same strain of mice. Our results show that T-cell help and proliferation may therefore be regulated independently.

Original languageEnglish
Pages (from-to)45-8
Number of pages4
Issue number1
Publication statusPublished - Jan 1989


  • Adoptive Transfer
  • Animals
  • Antibodies
  • Antibody Formation
  • B-Lymphocytes
  • Cattle
  • Cell Proliferation
  • Insulin
  • Mice
  • Mice, Inbred Strains
  • Swine
  • T-Lymphocytes


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