The systemic lupus erythematosus tri-nation study: longitudinal changes in physical and mental well-being

P Panopalis, M Petri, S Manzi, D Isenberg, Caroline Gordon, JL Senecal, JR Penrod, L Joseph, Y St Pierre, C Pineau, PR Fortin, N Sutcliffe, JR Goulet, D Choquette, T Grodzicky, JM Esdaile, AE Clarke

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43 Citations (Scopus)


OBJECTIVE: We have shown that SLE patients in Canada and the UK incurred 20% and 13% lower health costs than those in the US, respectively, but did not experience worse outcomes as expressed by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index. We now compare change in quality of life in these patients. Patients and METHODS: Seven hundred and fifteen SLE patients (Canada 231, US 269, UK 215) completed the SF-36 annually over four years. The annual change in the SF-36 Physical and Mental Component Summary (PCS and MCS) scores over the course of the study were summarized by estimating a linear trend for each individual patient using hierarchical modelling. Cross-country comparison of the slopes in the PCS and MCS scores was then performed using simultaneous regressions. RESULTS: The estimated mean annual changes (95% credible interval [CrI]) in the PCS scores in Canada, the US, and the UK were 0.18 (-0.07, 0.43), -0.05 (-0.27, 0.17), and 0.03 (-0.20, 0.27), respectively; the mean annual changes in the MCS scores were 0.15 (-0.04, 0.34), 0.23 (0.09, 0.37), and 0.08 (-0.10, 0.27), respectively. Regression results showed that the mean annual changes in PCS and MCS scores did not substantially differ across countries. CONCLUSION: Quality of life remained stable across countries. Despite Canadian and British patients incurring lower health costs, on average, patients experienced similar changes in physical and mental well-being.
Original languageEnglish
Pages (from-to)751-755
Number of pages5
Issue number6
Early online date12 Apr 2005
Publication statusPublished - 12 Apr 2005


  • direct healthcare costs
  • systemic lupus erythematosus
  • health status
  • quality of life
  • disease damage


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