The systemic inflammatory response syndrome is predictive of renal dysfunction in patients with non-paracetamol-induced acute liver failure

J A Leithead; J W Ferguson; C M Bates; J S Davidson; A Lee; A J Bathgate; P C Hayes; K J Simpson

doi:10.1136/gut.2008.154120

The systemic inflammatory response syndrome is predictive of renal dysfunction in patients with non-paracetamol-induced acute liver failure

J A Leithead, J W Ferguson, C M Bates, J S Davidson, A Lee, A J Bathgate, P C Hayes, K J Simpson

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

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Abstract

Although renal dysfunction is a common complication of acute liver failure (ALF) with significant prognostic implications, the pathophysiological mechanisms remain unclear. The current hypothesis suggests that the renal dysfunction may mirror the hepatorenal syndrome of cirrhosis. However, ALF has distinct clinical characteristics and the circulatory derangement may be more comparable with sepsis.

Original language	English
Pages (from-to)	443-9
Number of pages	7
Journal	Gut
Volume	58
Issue number	3
DOIs	https://doi.org/10.1136/gut.2008.154120
Publication status	Published - Mar 2009

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title = "The systemic inflammatory response syndrome is predictive of renal dysfunction in patients with non-paracetamol-induced acute liver failure",

abstract = "Although renal dysfunction is a common complication of acute liver failure (ALF) with significant prognostic implications, the pathophysiological mechanisms remain unclear. The current hypothesis suggests that the renal dysfunction may mirror the hepatorenal syndrome of cirrhosis. However, ALF has distinct clinical characteristics and the circulatory derangement may be more comparable with sepsis.",

author = "Leithead, {J A} and Ferguson, {J W} and Bates, {C M} and Davidson, {J S} and A Lee and Bathgate, {A J} and Hayes, {P C} and Simpson, {K J}",

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AU - Leithead, J A

AU - Ferguson, J W

AU - Bates, C M

AU - Davidson, J S

AU - Lee, A

AU - Bathgate, A J

AU - Hayes, P C

AU - Simpson, K J

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N2 - Although renal dysfunction is a common complication of acute liver failure (ALF) with significant prognostic implications, the pathophysiological mechanisms remain unclear. The current hypothesis suggests that the renal dysfunction may mirror the hepatorenal syndrome of cirrhosis. However, ALF has distinct clinical characteristics and the circulatory derangement may be more comparable with sepsis.

AB - Although renal dysfunction is a common complication of acute liver failure (ALF) with significant prognostic implications, the pathophysiological mechanisms remain unclear. The current hypothesis suggests that the renal dysfunction may mirror the hepatorenal syndrome of cirrhosis. However, ALF has distinct clinical characteristics and the circulatory derangement may be more comparable with sepsis.

U2 - 10.1136/gut.2008.154120

DO - 10.1136/gut.2008.154120

M3 - Article

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SN - 1468-3288

VL - 58

SP - 443

EP - 449

JO - Gut

JF - Gut

IS - 3

ER -

The systemic inflammatory response syndrome is predictive of renal dysfunction in patients with non-paracetamol-induced acute liver failure

Abstract

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