The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs

Shannon J Turley, Anne L Fletcher, Kutlu G Elpek

Research output: Contribution to journalArticlepeer-review

115 Citations (Scopus)

Abstract

T cells encounter their cognate antigens in specialized compartments of secondary lymphoid organs (SLOs). There, dendritic cells (DCs) present self and non-self antigens to T cells, and promote immunity or tolerance depending on the availability of danger signals. Resident stromal cells orchestrate the interaction between T cells and DCs by recruiting them to T cell zones and guiding their migration within SLOs. Recent studies have shown that SLO-resident stromal cells also have a crucial role in tolerance induction in the periphery. In this Review, we discuss the roles of SLO-resident DCs and stromal cells in shaping T cell responses.

Original languageEnglish
Pages (from-to)813-25
Number of pages13
JournalNature Reviews Immunology
Volume10
Issue number12
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Animals
  • Antigen-Presenting Cells
  • Antigens
  • Cell Movement
  • Hematopoietic System
  • Humans
  • Immune Tolerance
  • Lymphoid Tissue
  • Mice
  • Stromal Cells
  • T-Lymphocytes

Fingerprint

Dive into the research topics of 'The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs'. Together they form a unique fingerprint.

Cite this