Abstract
T cells encounter their cognate antigens in specialized compartments of secondary lymphoid organs (SLOs). There, dendritic cells (DCs) present self and non-self antigens to T cells, and promote immunity or tolerance depending on the availability of danger signals. Resident stromal cells orchestrate the interaction between T cells and DCs by recruiting them to T cell zones and guiding their migration within SLOs. Recent studies have shown that SLO-resident stromal cells also have a crucial role in tolerance induction in the periphery. In this Review, we discuss the roles of SLO-resident DCs and stromal cells in shaping T cell responses.
Original language | English |
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Pages (from-to) | 813-25 |
Number of pages | 13 |
Journal | Nature Reviews Immunology |
Volume | 10 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 2010 |
Keywords
- Animals
- Antigen-Presenting Cells
- Antigens
- Cell Movement
- Hematopoietic System
- Humans
- Immune Tolerance
- Lymphoid Tissue
- Mice
- Stromal Cells
- T-Lymphocytes