The solution structure of the heavy chain–only C5-Fc nanobody reveals exposed variable regions that are optimal for COVID-19 antigen interactions

Keyphrases

• COVID-19 100%
• Solution Structure 100%
• Fc Region 100%
• Nanobody 100%
• Antigen Interaction 100%
• Neutron 66%
• X-ray 66%
• Human IgG1 66%
• Top 100 33%
• Mass Spectra 33%
• Monte Carlo Simulation 33%
• Therapeutic Efficacy 33%
• R-factor 33%
• Glycans 33%
• Binding Affinity 33%
• Fusion Protein 33%
• X-ray Structure 33%
• Single Domain 33%
• Disulfide Bridge 33%
• Coronavirus 33%
• Size Reduction 33%
• Virus Neutralization 33%
• O-glycosylation 33%
• High Stability 33%
• IgG1 Antibody 33%
• N-linked Glycans 33%
• Neutralization Activity 33%
• Size Stability 33%
• Efficacy in Vivo 33%
• Scattering Modeling 33%
• Conformational Stability 33%
• Therapeutic Function 33%
• Conventional Antibodies 33%
• Llama 33%
• Neutron Structure 33%
• COVID-19 Virus 33%
• Guinier 33%
• Mercaptoethylamine 33%
• Asymmetric Solutions 33%

Biochemistry, Genetics and Molecular Biology

• X Ray 100%
• Single-Domain Antibody 100%
• Solution Structure 100%
• Polysaccharide 66%
• Solution and Solubility 33%
• Disulfide 33%
• Binding Affinity 33%
• Conformation 33%
• Chimeric Protein 33%
• R-Factor 33%
• Deglycosylation 33%
• SARS Coronavirus 33%
• Coronavirinae 33%
• Virus Neutralization 33%
• Llama 33%