The sleep phenotype of Borderline Personality Disorder: A systematic review and meta-analysis

Catherine Winsper; Nicole K Y Tang; Steven Marwaha; Suzet Tanya Lereya; Melanie Gibbs; Andrew Thompson; Swaran P Singh

doi:10.1016/j.neubiorev.2016.12.008

The sleep phenotype of Borderline Personality Disorder: A systematic review and meta-analysis

Catherine Winsper, Nicole K Y Tang, Steven Marwaha, Suzet Tanya Lereya, Melanie Gibbs, Andrew Thompson, Swaran P Singh

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

Abstract

AIM: To delineate the sleep profile of Borderline Personality Disorder (BPD).

METHOD: A meta-analysis to synthesise findings on the objective and subjective sleep characteristics of BPD.

RESULTS: We identified 32 studies published between 1980 and December 2015. Meta-analysis indicated significant differences between BPD and healthy control groups across objective sleep continuity (sleep onset latency, total sleep time, sleep efficiency) and architecture (rapid eye movement latency/density, slow wave sleep) measures, and self-reported sleep problems (nightmares, sleep quality). Findings were independent of depression (in clinical and community populations), and concomitant psychotropic medication use. There were few significant differences between BPD and clinical (majority depressed) control groups.

CONCLUSION: BPD is associated with comparable sleep disturbances to those observed in depression. These disturbances are not solely attributable to comorbid depression. Given growing evidence that sleep disturbance may exacerbate emotional dysregulation and suicide risk, treatments for BPD should explicitly address sleep problems. Future studies should utilise prospective designs to ascertain whether (and in which circumstances) sleep problems predate or follow the onset of the disorder.

Original language	English
Pages (from-to)	48-67
Number of pages	20
Journal	Neuroscience and biobehavioral reviews
Volume	73
Early online date	15 Dec 2016
DOIs	https://doi.org/10.1016/j.neubiorev.2016.12.008
Publication status	Published - Feb 2017

Keywords

Borderline Personality Disorder
Humans
Phenotype
Sleep
Sleep Wake Disorders

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neubiorev.2016.12.008

http://wrap.warwick.ac.uk/84465/Licence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

Cite this

@article{90890d33041c4901a96737dd59f0d957,

title = "The sleep phenotype of Borderline Personality Disorder: A systematic review and meta-analysis",

abstract = "AIM: To delineate the sleep profile of Borderline Personality Disorder (BPD).METHOD: A meta-analysis to synthesise findings on the objective and subjective sleep characteristics of BPD.RESULTS: We identified 32 studies published between 1980 and December 2015. Meta-analysis indicated significant differences between BPD and healthy control groups across objective sleep continuity (sleep onset latency, total sleep time, sleep efficiency) and architecture (rapid eye movement latency/density, slow wave sleep) measures, and self-reported sleep problems (nightmares, sleep quality). Findings were independent of depression (in clinical and community populations), and concomitant psychotropic medication use. There were few significant differences between BPD and clinical (majority depressed) control groups.CONCLUSION: BPD is associated with comparable sleep disturbances to those observed in depression. These disturbances are not solely attributable to comorbid depression. Given growing evidence that sleep disturbance may exacerbate emotional dysregulation and suicide risk, treatments for BPD should explicitly address sleep problems. Future studies should utilise prospective designs to ascertain whether (and in which circumstances) sleep problems predate or follow the onset of the disorder.",

keywords = "Borderline Personality Disorder, Humans, Phenotype, Sleep, Sleep Wake Disorders",

author = "Catherine Winsper and Tang, {Nicole K Y} and Steven Marwaha and Lereya, {Suzet Tanya} and Melanie Gibbs and Andrew Thompson and Singh, {Swaran P}",

year = "2017",

month = feb,

doi = "10.1016/j.neubiorev.2016.12.008",

language = "English",

volume = "73",

pages = "48--67",

journal = "Neuroscience and biobehavioral reviews",

issn = "0149-7634",

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T1 - The sleep phenotype of Borderline Personality Disorder

T2 - A systematic review and meta-analysis

AU - Winsper, Catherine

AU - Tang, Nicole K Y

AU - Marwaha, Steven

AU - Lereya, Suzet Tanya

AU - Gibbs, Melanie

AU - Thompson, Andrew

AU - Singh, Swaran P

PY - 2017/2

Y1 - 2017/2

N2 - AIM: To delineate the sleep profile of Borderline Personality Disorder (BPD).METHOD: A meta-analysis to synthesise findings on the objective and subjective sleep characteristics of BPD.RESULTS: We identified 32 studies published between 1980 and December 2015. Meta-analysis indicated significant differences between BPD and healthy control groups across objective sleep continuity (sleep onset latency, total sleep time, sleep efficiency) and architecture (rapid eye movement latency/density, slow wave sleep) measures, and self-reported sleep problems (nightmares, sleep quality). Findings were independent of depression (in clinical and community populations), and concomitant psychotropic medication use. There were few significant differences between BPD and clinical (majority depressed) control groups.CONCLUSION: BPD is associated with comparable sleep disturbances to those observed in depression. These disturbances are not solely attributable to comorbid depression. Given growing evidence that sleep disturbance may exacerbate emotional dysregulation and suicide risk, treatments for BPD should explicitly address sleep problems. Future studies should utilise prospective designs to ascertain whether (and in which circumstances) sleep problems predate or follow the onset of the disorder.

AB - AIM: To delineate the sleep profile of Borderline Personality Disorder (BPD).METHOD: A meta-analysis to synthesise findings on the objective and subjective sleep characteristics of BPD.RESULTS: We identified 32 studies published between 1980 and December 2015. Meta-analysis indicated significant differences between BPD and healthy control groups across objective sleep continuity (sleep onset latency, total sleep time, sleep efficiency) and architecture (rapid eye movement latency/density, slow wave sleep) measures, and self-reported sleep problems (nightmares, sleep quality). Findings were independent of depression (in clinical and community populations), and concomitant psychotropic medication use. There were few significant differences between BPD and clinical (majority depressed) control groups.CONCLUSION: BPD is associated with comparable sleep disturbances to those observed in depression. These disturbances are not solely attributable to comorbid depression. Given growing evidence that sleep disturbance may exacerbate emotional dysregulation and suicide risk, treatments for BPD should explicitly address sleep problems. Future studies should utilise prospective designs to ascertain whether (and in which circumstances) sleep problems predate or follow the onset of the disorder.

KW - Borderline Personality Disorder

KW - Humans

KW - Phenotype

KW - Sleep

KW - Sleep Wake Disorders

U2 - 10.1016/j.neubiorev.2016.12.008

DO - 10.1016/j.neubiorev.2016.12.008

M3 - Review article

C2 - 27988314

SN - 0149-7634

VL - 73

SP - 48

EP - 67

JO - Neuroscience and biobehavioral reviews

JF - Neuroscience and biobehavioral reviews

ER -

The sleep phenotype of Borderline Personality Disorder: A systematic review and meta-analysis

Abstract

Keywords

UN SDGs

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