The role of valve stiffness in the insurgence of deep vein thrombosis

Zoe Schofield, Hosam Alden Baksamawi, Joana Campos, Alessio Alexiadis, Gerard Nash, Alexander Brill, Daniele Vigolo

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Abstract

Deep vein thrombosis is a life-threatening development of blood clots in deep veins. Immobility and blood flow stagnancy are typical risk factors indicating that fluid dynamics play an important role in the initiation of venous clots. However, the roles of physical parameters of the valves and flow conditions in deep vein thrombosis initiation have not been fully understood. Here, we describe a microfluidics in vitro method that enabled us to explore the role of valve elasticity using in situ fabrication and characterisation. In our experimental model the stiffness of each valve leaflet can be controlled independently, and various flow conditions were tested. The resulting complex flow patterns were detected using ghost particle velocimetry and linked to localised thrombus formation using whole blood and an aqueous suspension of polystyrene particles. In particular, valves with leaflets of similar stiffness had clot formation on the valve tips whereas valves with leaflets of different stiffness had clot formation in the valve pocket.
Original languageEnglish
Article number65
Number of pages10
JournalCommunications Materials
Volume1
DOIs
Publication statusPublished - 16 Sep 2020

Keywords

  • Thrombosis
  • Biomedical engineering
  • Fluid dynamics
  • Bioinspired materials

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