The role of triacylglycerols and repurposing DGAT1 inhibitors for the treatment of Mycobacterium tuberculosis

Alice R Moorey; Gurdyal S Besra

doi:10.1016/j.tcsw.2022.100083

The role of triacylglycerols and repurposing DGAT1 inhibitors for the treatment of Mycobacterium tuberculosis

Alice R Moorey
, Gurdyal S Besra^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Latent tuberculosis poses a significant threat to global health through the incubation of undiagnosed infections within the community, and through its tolerance to antibiotics. This Special Features article explores the mechanisms by which the dormant Mycobacterium tuberculosis pathogen can store energy in the form of lipid inclusion bodies and triacylglycerols, which may be key in the development of novel therapeutics to treat TB.

Original language	English
Article number	100083
Number of pages	4
Journal	The Cell Surface
Volume	8
Early online date	15 Oct 2022
DOIs	https://doi.org/10.1016/j.tcsw.2022.100083
Publication status	Published - Dec 2022

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Mycobacterium tuberculosis
Triacylglycerols
Tgs

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10.1016/j.tcsw.2022.100083Licence: Creative Commons: Attribution (CC BY)

MooreyA2022roleFinal published version, 1.09 MBLicence: Creative Commons: Attribution (CC BY)

Cite this

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title = "The role of triacylglycerols and repurposing DGAT1 inhibitors for the treatment of Mycobacterium tuberculosis",

abstract = "Latent tuberculosis poses a significant threat to global health through the incubation of undiagnosed infections within the community, and through its tolerance to antibiotics. This Special Features article explores the mechanisms by which the dormant Mycobacterium tuberculosis pathogen can store energy in the form of lipid inclusion bodies and triacylglycerols, which may be key in the development of novel therapeutics to treat TB. ",

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AU - Moorey, Alice R

AU - Besra, Gurdyal S

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N2 - Latent tuberculosis poses a significant threat to global health through the incubation of undiagnosed infections within the community, and through its tolerance to antibiotics. This Special Features article explores the mechanisms by which the dormant Mycobacterium tuberculosis pathogen can store energy in the form of lipid inclusion bodies and triacylglycerols, which may be key in the development of novel therapeutics to treat TB.

AB - Latent tuberculosis poses a significant threat to global health through the incubation of undiagnosed infections within the community, and through its tolerance to antibiotics. This Special Features article explores the mechanisms by which the dormant Mycobacterium tuberculosis pathogen can store energy in the form of lipid inclusion bodies and triacylglycerols, which may be key in the development of novel therapeutics to treat TB.

KW - Mycobacterium tuberculosis

KW - Triacylglycerols

KW - Tgs

U2 - 10.1016/j.tcsw.2022.100083

DO - 10.1016/j.tcsw.2022.100083

M3 - Review article

C2 - 36277080

SN - 2468-2330

VL - 8

JO - The Cell Surface

JF - The Cell Surface

M1 - 100083

ER -

The role of triacylglycerols and repurposing DGAT1 inhibitors for the treatment of Mycobacterium tuberculosis

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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Cite this