The role of T and B cells in atherosclerosis: potential clinical implications

Ingrid Dumitriu, J C Kaski

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

The chronic inflammation process that characterises atherosclerosis involves both the innate and adaptive arms of the immune system. Several lines of evidence have recently highlighted pivotal roles for T and B lymphocytes - cells that belong to the adaptive immune system - in the development and progression of atherosclerosis. In this review, we summarise the current knowledge on the roles of adaptive immune responses in atherosclerosis and present our views on how a better understanding of these immune mechanisms could shape future therapies to slow down or even prevent this disease.

Original languageEnglish
Pages (from-to)4159-71
Number of pages13
JournalCurrent pharmaceutical design
Volume17
Issue number37
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Adaptive Immunity/drug effects
  • Animals
  • Antibodies, Monoclonal/administration & dosage
  • Atherosclerosis/drug therapy
  • B-Lymphocytes/drug effects
  • Endothelium, Vascular/drug effects
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage
  • Immunity, Innate/drug effects
  • Immunosuppressive Agents/administration & dosage
  • T-Lymphocytes/drug effects

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