The role of T and B cells in atherosclerosis: potential clinical implications

Ingrid Dumitriu, J C Kaski

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)


The chronic inflammation process that characterises atherosclerosis involves both the innate and adaptive arms of the immune system. Several lines of evidence have recently highlighted pivotal roles for T and B lymphocytes - cells that belong to the adaptive immune system - in the development and progression of atherosclerosis. In this review, we summarise the current knowledge on the roles of adaptive immune responses in atherosclerosis and present our views on how a better understanding of these immune mechanisms could shape future therapies to slow down or even prevent this disease.

Original languageEnglish
Pages (from-to)4159-71
Number of pages13
JournalCurrent pharmaceutical design
Issue number37
Publication statusPublished - Dec 2011


  • Adaptive Immunity/drug effects
  • Animals
  • Antibodies, Monoclonal/administration & dosage
  • Atherosclerosis/drug therapy
  • B-Lymphocytes/drug effects
  • Endothelium, Vascular/drug effects
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage
  • Immunity, Innate/drug effects
  • Immunosuppressive Agents/administration & dosage
  • T-Lymphocytes/drug effects


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