Abstract
The chronic inflammation process that characterises atherosclerosis involves both the innate and adaptive arms of the immune system. Several lines of evidence have recently highlighted pivotal roles for T and B lymphocytes - cells that belong to the adaptive immune system - in the development and progression of atherosclerosis. In this review, we summarise the current knowledge on the roles of adaptive immune responses in atherosclerosis and present our views on how a better understanding of these immune mechanisms could shape future therapies to slow down or even prevent this disease.
Original language | English |
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Pages (from-to) | 4159-71 |
Number of pages | 13 |
Journal | Current pharmaceutical design |
Volume | 17 |
Issue number | 37 |
DOIs | |
Publication status | Published - Dec 2011 |
Keywords
- Adaptive Immunity/drug effects
- Animals
- Antibodies, Monoclonal/administration & dosage
- Atherosclerosis/drug therapy
- B-Lymphocytes/drug effects
- Endothelium, Vascular/drug effects
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage
- Immunity, Innate/drug effects
- Immunosuppressive Agents/administration & dosage
- T-Lymphocytes/drug effects