Abstract
There is growing recognition of the critical role of platelets in inflammation and immune responses. Recent studies have indicated that antiplatelet medications may reduce mortality from infections and sepsis, which suggests possible clinical relevance of modifying platelet responses to inflammation. Platelets release numerous inflammatory mediators that have no known role in haemostasis. Many of these mediators modify leukocyte and endothelial responses to a range of different inflammatory stimuli. Additionally, platelets form aggregates with leukocytes and form bridges between leukocytes and endothelium, largely mediated by platelet P-selectin. Through their interactions with monocytes, neutrophils, lymphocytes and the endothelium, platelets are therefore important coordinators of inflammation and both innate and adaptive immune responses.
Original language | English |
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Pages (from-to) | 449-58 |
Number of pages | 10 |
Journal | Thrombosis and Haemostasis |
Volume | 114 |
Issue number | 3 |
DOIs | |
Publication status | Published - 31 Aug 2015 |
Keywords
- Animals
- Anti-Inflammatory Agents
- Blood Platelets
- Cell Communication
- Communicable Diseases
- Host-Pathogen Interactions
- Humans
- Inflammation
- Inflammation Mediators
- Leukocytes
- Neoplasms
- Platelet Adhesiveness
- Platelet Aggregation
- Platelet Aggregation Inhibitors
- Signal Transduction
- Journal Article
- Research Support, Non-U.S. Gov't
- Review