Projects per year
Abstract
Glucocorticoids (GCs) are steroids with profound anti-inflammatory and immunomodulatory activities. Synthetic GCs are widely used for managing chronic inflammatory and autoimmune conditions, as immunosuppressants in transplantation, and as anti-tumor agents in certain hematological cancers. However, prolonged GC exposure can cause adverse effects. A detailed understanding of GCs' mechanisms of action may enable harnessing of their desirable actions while minimizing harmful effects. Here, we review the impact on the GC biology of microRNAs, small non-coding RNAs that post-transcriptionally regulate gene expression. Emerging evidence indicates that microRNAs modulate GC production by the adrenal glands and the cells' responses to GCs. Furthermore, GCs influence cell proliferation, survival, and function at least in part by regulating microRNA expression. We propose that the beneficial effects of GCs may be enhanced through combination with reagents targeting specific microRNAs.
Original language | English |
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Pages (from-to) | 1865-1874 |
Journal | Journal of Biological Chemistry |
Volume | 293 |
Issue number | 6 |
Early online date | 4 Jan 2018 |
DOIs | |
Publication status | Published - 9 Feb 2018 |
Keywords
- epigenetics
- microRNA (miRNA)
- glucocorticoid
- glucocorticoid receptor
- apoptosis
- inflammation
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Dive into the research topics of 'The role of microRNAs in glucocorticoid action'. Together they form a unique fingerprint.Projects
- 2 Finished
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Centre for Musculoskeletal Ageing Research (linked to 18289 & 19482)
Lord, J. (Principal Investigator), Buckley, C. (Co-Investigator), Duda, J. (Co-Investigator), Dunn, W. (Co-Investigator), Miall, C. (Co-Investigator) & Greig, C. (Co-Investigator)
1/08/12 → 31/07/17
Project: Research Councils
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Innovative approaches to improving the safety and efficacy of glucocorticoids
Clark, A. (Principal Investigator)
1/06/12 → 15/10/17
Project: Research