The role of leukocyte-stromal interactions in chronic inflammatory joint disease

Angela Burman, Oliver Haworth, Paul Bradfield, Gregory Parsonage, Andrew Filer, Andrew M C Thomas, Esther Amft, Michael Salmon, Christopher D Buckley

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Rheumatoid arthritis (RA) is a debilitating, chronic, persistent inflammatory disease that is characterised by painful and swollen joints. The aetiology of RA is unknown, however whereas past research has concentrated on the role of immune or inflammatory infiltrating cells in inflammation, it is becoming clear that stromal cells play a critical part in regulating the quality and duration of an inflammatory response. In this review we assess the role of fibroblasts within the inflamed synovium in modulating immune responses; in particular we examine the role of stromal cells in the switch from resolving to persistent inflammation as is found in the rheumatoid synovium.

Original languageEnglish
Pages (from-to)10-16
Number of pages7
JournalJoint Bone Spine
Issue number1
Early online date8 Jun 2004
Publication statusPublished - Jan 2005


  • Animals
  • Arthritis, Rheumatoid
  • Cell Communication
  • Chronic Disease
  • Humans
  • Leukocytes
  • Stromal Cells
  • Synovitis


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