The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen

Steve Watson; N Asazuma; Ben Atkinson; Oscar Berlanga; D Best; R Bobe; G Jarvis; S Marshall; D Snell; M Stafford; D Tulasne; Johnathan Wilde; P Wonerow; Jonathan Frampton

The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen

Steve Watson
, N Asazuma
, Ben Atkinson
, Oscar Berlanga
, D Best
, R Bobe
, G Jarvis
, S Marshall
, D Snell
, M Stafford
, D Tulasne
, Johnathan Wilde
, P Wonerow
, Jonathan Frampton

Research output: Contribution to journal › Review article

112 Citations (Scopus)

Abstract

The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor gamma-chain (FcR gamma-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.

Original language	English
Pages (from-to)	276-88
Number of pages	13
Journal	Journal of Thrombosis and Haemostasis
Volume	86
Issue number	1
Publication status	Published - 1 Jul 2001

Cite this

@article{ec5db8e0e5b34373adb986d1755f966f,

title = "The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen",

abstract = "The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor gamma-chain (FcR gamma-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.",

author = "Steve Watson and N Asazuma and Ben Atkinson and Oscar Berlanga and D Best and R Bobe and G Jarvis and S Marshall and D Snell and M Stafford and D Tulasne and Johnathan Wilde and P Wonerow and Jonathan Frampton",

year = "2001",

month = jul,

day = "1",

language = "English",

volume = "86",

pages = "276--88",

journal = "Journal of Thrombosis and Haemostasis",

issn = "1538-7836",

publisher = "Wiley",

number = "1",

}

TY - JOUR

T1 - The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen

AU - Watson, Steve

AU - Asazuma, N

AU - Atkinson, Ben

AU - Berlanga, Oscar

AU - Best, D

AU - Bobe, R

AU - Jarvis, G

AU - Marshall, S

AU - Snell, D

AU - Stafford, M

AU - Tulasne, D

AU - Wilde, Johnathan

AU - Wonerow, P

AU - Frampton, Jonathan

PY - 2001/7/1

Y1 - 2001/7/1

N2 - The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor gamma-chain (FcR gamma-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.

AB - The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor gamma-chain (FcR gamma-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.

M3 - Review article

C2 - 11487016

SN - 1538-7836

VL - 86

SP - 276

EP - 288

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

IS - 1

ER -

The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen

Abstract

Fingerprint

Cite this