The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen

Steve Watson; N Asazuma; Ben Atkinson; Oscar Berlanga; D Best; R Bobe; G Jarvis; S Marshall; D Snell; M Stafford; D Tulasne; Johnathan Wilde; P Wonerow; Jonathan Frampton

The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen

Steve Watson, N Asazuma, Ben Atkinson, Oscar Berlanga, D Best, R Bobe, G Jarvis, S Marshall, D Snell, M Stafford, D Tulasne, Johnathan Wilde, P Wonerow, Jonathan Frampton

Research output: Contribution to journal › Review article

112 Citations (Scopus)

Abstract

The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor gamma-chain (FcR gamma-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.

Original language	English
Pages (from-to)	276-88
Number of pages	13
Journal	Journal of Thrombosis and Haemostasis
Volume	86
Issue number	1
Publication status	Published - 1 Jul 2001

Cite this

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title = "The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen",

abstract = "The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor gamma-chain (FcR gamma-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.",

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AU - Watson, Steve

AU - Asazuma, N

AU - Atkinson, Ben

AU - Berlanga, Oscar

AU - Best, D

AU - Bobe, R

AU - Jarvis, G

AU - Marshall, S

AU - Snell, D

AU - Stafford, M

AU - Tulasne, D

AU - Wilde, Johnathan

AU - Wonerow, P

AU - Frampton, Jonathan

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N2 - The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor gamma-chain (FcR gamma-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.

AB - The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor gamma-chain (FcR gamma-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.

M3 - Review article

C2 - 11487016

SN - 1538-7836

VL - 86

SP - 276

EP - 288

JO - Journal of Thrombosis and Haemostasis

JF - Journal of Thrombosis and Haemostasis

IS - 1

ER -

The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen

Abstract

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