The role of iron in Campylobacter gene regulation, metabolism and oxidative stress defense

AH van Vliet, JM Ketley, SF Park, Charles Penn

Research output: Contribution to journalReview article

95 Citations (Scopus)


Enteric Campylobacter species cause gastrointestinal diseases in humans. Like almost all organisms, campylobacters have an absolute requirement for iron, but are faced with variable availability of iron in the environment and host tissues. Campylobacters have developed mechanisms to scavenge sufficient iron for metabolism and growth. However, iron also participates in the formation of reactive oxygen species, and this forces pathogens to maintain intracellular iron homeostasis and to cope with oxidative stresses. The presence of two separate, but possibly overlapping iron-responsive regulatory systems, which regulate iron acquisition and oxidative stress defense, and the presence of genes encoding multiple iron acquisition and detoxification systems in Campylobacter indicate the central role that iron plays in Campylobacter gene regulation and virulence. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)173-186
Number of pages14
JournalFEMS Microbiology Reviews
Publication statusPublished - 1 Jan 2002


  • oxidative stress defense
  • ferric uptake regulator
  • Campylobacter
  • PerR
  • iron transport
  • iron storage
  • Fur


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