The Role of Hepcidin-25 in Kidney Transplantation

Winnie Chan, Douglas G Ward, Andrew McClean, Jos A Bosch, David Jones, Okdeep Kaur, Mark Drayson, Alison Whitelegg, Tariq Iqbal, Philip G McTernan, Chris Tselepis, Richard Borrows

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


BACKGROUND: Hepcidin-25 is a peptide hormone involved in iron absorption and homeostasis and found at increased serum levels in conditions involving systemic inflammation, renal dysfunction, and increased adiposity. Hepcidin may play a role in the pathogenesis of anemia, but its role in kidney transplantation is undefined. METHODS: This study enrolled 100 stable patients beyond 12 months after transplantation, from a large single United Kingdom center. Serum hepcidin-25 level, and relevant demographic and laboratory data pertinent to posttransplantation anemia, were measured and collected. Independent predictors of serum hepcidin were evaluated, and the relationship between hepcidin and hemoglobin, assessed. RESULTS: Independent associations were seen between higher hepcidin levels and allograft dysfunction (estimated glomerular filtration rate), increased inflammation (high-sensitivity C-reactive peptide), higher transferrin saturation (a marker of iron stores), and the use of marrow-suppressive medication (P
Original languageEnglish
Pages (from-to)1390-5
Number of pages6
Issue number11
Publication statusPublished - 2 Apr 2013


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