The role of hemochromatosis susceptibility gene mutations in protecting against iron deficiency in celiac disease

Jeffrey R Butterworth; Brian T Cooper; William M C Rosenberg; Michael Purkiss; Shirley Jobson; Mark Hathaway; David Briggs; W Martin Howell; Gordon M Wood; David H Adams; Tariq H Iqbal

The role of hemochromatosis susceptibility gene mutations in protecting against iron deficiency in celiac disease

Jeffrey R Butterworth, Brian T Cooper, William M C Rosenberg, Michael Purkiss, Shirley Jobson, Mark Hathaway, David Briggs, W Martin Howell, Gordon M Wood, David H Adams, Tariq H Iqbal

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Celiac disease and hereditary hemochromatosis are common HLA-defined conditions in northwestern Europe. We sought to determine whether there is a genetic relationship between the 2 diseases and if hemochromatosis susceptibility gene (HFE) mutations are protective against iron deficiency in celiac disease.

Original language	English
Pages (from-to)	444-9
Number of pages	6
Journal	Gastroenterology
Volume	123
Issue number	2
Publication status	Published - Aug 2002

Keywords

Adult
Celiac Disease
Genetic Predisposition to Disease
HLA Antigens
HLA-A Antigens
HLA-DQ Antigens
HLA-DQ beta-Chains
Hemochromatosis
Hemoglobins
Histocompatibility Antigens Class I
Humans
Iron
Linkage Disequilibrium
Membrane Proteins
Mutation

Cite this

@article{38a9db155357458386e3485a82970c64,

title = "The role of hemochromatosis susceptibility gene mutations in protecting against iron deficiency in celiac disease",

abstract = "Celiac disease and hereditary hemochromatosis are common HLA-defined conditions in northwestern Europe. We sought to determine whether there is a genetic relationship between the 2 diseases and if hemochromatosis susceptibility gene (HFE) mutations are protective against iron deficiency in celiac disease.",

keywords = "Adult, Celiac Disease, Genetic Predisposition to Disease, HLA Antigens, HLA-A Antigens, HLA-DQ Antigens, HLA-DQ beta-Chains, Hemochromatosis, Hemoglobins, Histocompatibility Antigens Class I, Humans, Iron, Linkage Disequilibrium, Membrane Proteins, Mutation",

author = "Butterworth, {Jeffrey R} and Cooper, {Brian T} and Rosenberg, {William M C} and Michael Purkiss and Shirley Jobson and Mark Hathaway and David Briggs and Howell, {W Martin} and Wood, {Gordon M} and Adams, {David H} and Iqbal, {Tariq H}",

year = "2002",

month = aug,

language = "English",

volume = "123",

pages = "444--9",

journal = "Gastroenterology",

issn = "0016-5085",

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TY - JOUR

T1 - The role of hemochromatosis susceptibility gene mutations in protecting against iron deficiency in celiac disease

AU - Butterworth, Jeffrey R

AU - Cooper, Brian T

AU - Rosenberg, William M C

AU - Purkiss, Michael

AU - Jobson, Shirley

AU - Hathaway, Mark

AU - Briggs, David

AU - Howell, W Martin

AU - Wood, Gordon M

AU - Adams, David H

AU - Iqbal, Tariq H

PY - 2002/8

Y1 - 2002/8

N2 - Celiac disease and hereditary hemochromatosis are common HLA-defined conditions in northwestern Europe. We sought to determine whether there is a genetic relationship between the 2 diseases and if hemochromatosis susceptibility gene (HFE) mutations are protective against iron deficiency in celiac disease.

AB - Celiac disease and hereditary hemochromatosis are common HLA-defined conditions in northwestern Europe. We sought to determine whether there is a genetic relationship between the 2 diseases and if hemochromatosis susceptibility gene (HFE) mutations are protective against iron deficiency in celiac disease.

KW - Adult

KW - Celiac Disease

KW - Genetic Predisposition to Disease

KW - HLA Antigens

KW - HLA-A Antigens

KW - HLA-DQ Antigens

KW - HLA-DQ beta-Chains

KW - Hemochromatosis

KW - Hemoglobins

KW - Histocompatibility Antigens Class I

KW - Humans

KW - Iron

KW - Linkage Disequilibrium

KW - Membrane Proteins

KW - Mutation

M3 - Article

C2 - 12145797

SN - 0016-5085

VL - 123

SP - 444

EP - 449

JO - Gastroenterology

JF - Gastroenterology

IS - 2

ER -

The role of hemochromatosis susceptibility gene mutations in protecting against iron deficiency in celiac disease

Abstract

Keywords

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