The role of glutathione in DNA damage by potassium bromate in vitro

Jason Parsons, J K Chipman

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)


We have investigated the role of reduced glutathione (GSH) in the genetic toxicity of the rodent renal carcinogen potassium bromate (KBrO(3)). A statistically significant increase in the concentration of 8-oxodeoxyguanosine (8-oxodG) relative to deoxyguanosine was measured following incubation of calf thymus DNA with KBrO(3) and GSH or N-acetylcysteine (NACys). This was dependent on these thiols and was associated with the loss of GSH and production of oxidized glutathione. A short-lived (
Original languageEnglish
Pages (from-to)311-316
Number of pages6
Issue number4
Publication statusPublished - Jul 2000


  • Bromates
  • Animals
  • Chlorates
  • DNA Damage
  • Glutathione
  • Humans
  • Carcinogens
  • Deoxyguanosine
  • Chromatography, High Pressure Liquid
  • Glutathione Disulfide
  • Potassium Compounds
  • Rats
  • Acetylcysteine
  • Iodates
  • Time Factors
  • Comet Assay
  • Free Radicals
  • Leukocytes
  • Cattle
  • Sulfhydryl Compounds
  • Epithelial Cells
  • Electron Spin Resonance Spectroscopy
  • Thymus Gland
  • DNA
  • Kidney
  • Cell Line


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