The role of CD28 and CTLA-4 in regulatory T cell biology

David Sansom, Lucy Walker

Research output: Contribution to journalArticle

225 Citations (Scopus)


The profound influence of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) on T-cell immunity has been known for over a decade, yet the precise roles played by these molecules still continue to emerge. Initially viewed as molecules that provide cell-intrinsic costimulatory and inhibitory signals, recent evidence suggests that both CD28 and CTLA-4 are also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Tregs). Here we review the main features of the CD28 and CTLA-4 system and examine how these impact upon Treg biology.
Original languageEnglish
Pages (from-to)131-48
Number of pages18
JournalImmunological Reviews
Publication statusPublished - 1 Aug 2006


  • regulatory T cells
  • cytotoxic T-lymphocyte antigen-4
  • CD28


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