Projects per year
The profound influence of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) on T-cell immunity has been known for over a decade, yet the precise roles played by these molecules still continue to emerge. Initially viewed as molecules that provide cell-intrinsic costimulatory and inhibitory signals, recent evidence suggests that both CD28 and CTLA-4 are also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Tregs). Here we review the main features of the CD28 and CTLA-4 system and examine how these impact upon Treg biology.
- regulatory T cells
- cytotoxic T-lymphocyte antigen-4
FingerprintDive into the research topics of 'The role of CD28 and CTLA-4 in regulatory T cell biology'. Together they form a unique fingerprint.
- 1 Finished
1/09/04 → 30/11/08
Project: Research Councils