The role of bone marrow-derived cells in venous thromboembolism

Joana Campos; Alexander Brill

doi:10.1016/j.biocel.2020.105850

The role of bone marrow-derived cells in venous thromboembolism

Joana Campos, Alexander Brill

Cardiovascular Sciences

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1 Citation (Scopus)

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Abstract

Venous thrombosis is a life-threatening condition with high morbidity and mortality. Abnormal functioning of different cells in the blood is an integral part of its pathogenesis. In this review, we describe the contribution of bone marrow-derived cells to the development of this debilitating disease. We present both epidemiological and clinical data demonstrating involvement of various cell types in venous thrombosis, and discuss potential mechanisms underlying these effects. Modern concepts including recently discovered new paradigms in thrombosis, such as neutrophil extracellular traps, mast cells, and polyphosphate, are summarized.

Original language	English
Article number	105850
Number of pages	5
Journal	The International Journal of Biochemistry & Cell Biology
Volume	128
Early online date	17 Sept 2020
DOIs	https://doi.org/10.1016/j.biocel.2020.105850
Publication status	Published - Nov 2020

Keywords

Deep vein thrombosis
Lymphocytes
Monocytes
Neutrophils
Platelets
Red blood cells
ast cells

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AB - Venous thrombosis is a life-threatening condition with high morbidity and mortality. Abnormal functioning of different cells in the blood is an integral part of its pathogenesis. In this review, we describe the contribution of bone marrow-derived cells to the development of this debilitating disease. We present both epidemiological and clinical data demonstrating involvement of various cell types in venous thrombosis, and discuss potential mechanisms underlying these effects. Modern concepts including recently discovered new paradigms in thrombosis, such as neutrophil extracellular traps, mast cells, and polyphosphate, are summarized.

KW - Deep vein thrombosis

KW - Lymphocytes

KW - Monocytes

KW - Neutrophils

KW - Platelets

KW - Red blood cells

KW - ast cells

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The role of bone marrow-derived cells in venous thromboembolism

Abstract

Keywords

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