Venous thrombosis is a life-threatening condition with high morbidity and mortality. Abnormal functioning of different cells in the blood is an integral part of its pathogenesis. In this review, we describe the contribution of bone marrow-derived cells to the development of this debilitating disease. We present both epidemiological and clinical data demonstrating involvement of various cell types in venous thrombosis, and discuss potential mechanisms underlying these effects. Modern concepts including recently discovered new paradigms in thrombosis, such as neutrophil extracellular traps, mast cells, and polyphosphate, are summarized.
|Number of pages||5|
|Journal||The International Journal of Biochemistry & Cell Biology|
|Early online date||17 Sept 2020|
|Publication status||Published - Nov 2020|
- Deep vein thrombosis
- Red blood cells
- ast cells