The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer

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Tumour-infiltrating immune cells have been widely implicated to play a significant role in carcinogenesis, through both pro- or anti-tumour effects. The multi-faceted effects of lung cancer associated T lymphocytes have been extensively studied, and yet, the role of B lymphocytes remains an area less studied. In this review, we will describe the current understanding of the role of tumour-infiltrating B lymphocytes in NSCLC, discuss their prognostic significance, their functionality within the tumour microenvironment and ultimately how we might harness B-cell biology to develop B-cell therapeutic strategies in cancer.
Original languageEnglish
Pages (from-to)325-342
JournalCancer Immunology Immunotherapy
Issue number3
Early online date4 Jan 2020
Publication statusE-pub ahead of print - 4 Jan 2020


  • B lymphocyte
  • Humoral Immunity
  • Immunoglobulin
  • Non-small-cell lung cancer (NSCLC)
  • Tumour -infiltrating B lymphocyte (TIL-B)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research


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