The main functional roles attributed to the centrosome, the major microtubule organizing center (MTOC) of metazoans, are related to cell locomotion, sensory perception and division. The role of vesicular trafficking in the regulation of the centrosome cycle has been largely unexplored. Recently, however, several studies have indicated the involvement of molecules and/or complexes of the trafficking routes in centrosome positioning, duplication and regulation. Functional screens have revealed communication between the outer nuclear envelope, the Golgi apparatus, the endosomal recycling compartment and centrosomes, while other studies underline the involvement of the ESCRT complex proteins in centrosome function. In this commentary, we discuss our recent study, which shows the involvement of an endosomal Rho protein, namely RhoD, in centrosome duplication and possible links between the centrosome's structural and functional integrity to vesicular trafficking.
Bibliographical noteM1 - 2
Kyrkou, Athena Soufi, Maria Bahtz, Ramona Ferguson, Charles Bai, Maria Parton, Robert G Hoffmann, Ingrid Zerial, Marino Fotsis, Theodore Murphy, Carol eng Comment 2013/02/21 06:00 Small GTPases. 2013 Apr-Jun;4(2):116-22. doi: 10.4161/sgtp.23707. Epub 2013 Feb 19.
- Animals Centrosome/*physiology G1 Phase/*physiology Humans Mutation/*genetics S Phase/*physiology Skin/*pathology rho GTP-Binding Proteins/*genetics