The respiratory responses to the combined activation of the muscle metaboreflex and the ventilatory chemoreflex.

CK Lykidis, Prem Kumar, George Balanos

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The excessive hyperventilation seen during exercise in chronic heart failure (CHF) contributes to the limited exercise capacity in this condition. The hyperactivation of reflexes originating, independently, from muscle (ergoreflex) and from chemoreceptors (chemoreflex) has been suggested to play an important part in the mediation of the CHF ventilatory abnormalities. In this study we aimed to assess the ventilatory responses to the combined activation of the muscle ergoreflex and the ventilatory chemoreflex, achieved by post-exercise circulatory occlusion (PECO) and euoxic hypercapnia (end-tidal PCO(2) = 7 mmHg above normal), respectively.Three healthy women and three healthy men (29.33 +/- 1.28 yrs; mean +/- SD) undertook four trials, in random order, separated from each other by 30 min of rest: 2 min of isometric handgrip exercise followed by 2 min of PECO with hypercapnia, 2 min of isometric handgrip exercise followed by 2 min of PECO while breathing room air, 4 min of rest with hypercapnia and 4 min of rest while breathing room air.Ventilation (V(E)) was significantly elevated by the ventilatory chemoreflex and it was further elevated by 5.13+/-0.83 L/min (P
Original languageEnglish
Pages (from-to)281-7
Number of pages7
JournalAdvances in Experimental Medicine and Biology
Volume648
DOIs
Publication statusPublished - 1 Jan 2009

Keywords

  • Ventilatory chemoreflex
  • Postexercise ventilatory occlusion
  • Muscle metaboreflex
  • Respiratory responses
  • Ergoreflex human

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